Rise in Insulin Resistance Is Associated With Escalated Telomere Attrition

(Source: Circulation, journal of the American Heart Association)

Abstract:

Background— Insulin resistance predisposes to cardiovascular disease and shortens human lifespan. We therefore tested the hypothesis that a rise in insulin resistance in concert with gain in body mass is associated with accelerated white blood cell telomere attrition.

Methods and Results— We measured white blood cell telomere dynamics and age-related changes in insulin resistance and body mass index in young adults of the Bogalusa Heart Study. Over 10.1 to 12.8 years, the relative changes in telomere length were correlated with the homeostasis model assessment of insulin resistance (r=–0.531, P<0.001) and changes in the body mass index (r=–0.423, P<0.001).

Conclusions— These findings provide the first tangible nexus of telomere biology with insulin resistance and adiposity in humans.

From Dayna Dye, Editor, Life Extension Update:

The authors speculate that “oxidative stress, by enhancing telomere erosion per replication, and inflammation, through increasing WBC [white blood cell] turnover, are responsible for the increase in telomere erosion with a rise in insulin resistance in the present study cohort.” They conclude that “Insulin resistance and obesity accelerate aging because they are states of increased oxidative stress and inflammation, which bring about a shorter lifespan. In biological terms, an accelerated WBC telomere attrition rate in insulin resistance and obese states is an affirmation of this concept.”